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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM2
All Species:
31.52
Human Site:
S689
Identified Species:
46.22
UniProt:
P49736
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49736
NP_004517.2
904
101896
S689
S
H
V
R
H
H
P
S
N
K
E
E
E
G
L
Chimpanzee
Pan troglodytes
XP_001136482
895
100908
S680
S
H
V
R
H
H
P
S
N
K
E
E
E
G
L
Rhesus Macaque
Macaca mulatta
XP_001099580
870
97929
V663
R
F
D
I
L
C
V
V
R
D
T
V
D
P
V
Dog
Lupus familis
XP_541736
1001
113024
P786
G
S
H
I
R
H
H
P
S
N
K
E
E
G
L
Cat
Felis silvestris
Mouse
Mus musculus
P97310
904
102059
S689
S
H
V
R
H
H
P
S
N
K
K
D
E
G
L
Rat
Rattus norvegicus
NP_001101343
905
102125
S690
S
H
V
R
H
H
P
S
N
K
K
D
E
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518428
911
102482
S696
S
H
V
K
H
H
P
S
N
K
E
E
E
E
V
Chicken
Gallus gallus
NP_001006139
888
100332
G676
S
H
V
K
H
H
P
G
S
K
E
A
V
N
G
Frog
Xenopus laevis
P55861
886
100243
S674
S
H
I
K
H
H
P
S
S
K
D
I
A
N
G
Zebra Danio
Brachydanio rerio
NP_775364
880
98286
S668
S
H
I
K
H
H
P
S
N
K
E
G
G
V
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
P673
H
S
H
M
K
H
H
P
S
E
E
E
Q
P
E
Honey Bee
Apis mellifera
XP_395109
1005
114136
T793
S
H
I
K
H
H
P
T
N
A
G
K
I
I
S
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
T570
G
V
M
T
M
F
D
T
D
G
F
L
T
I
E
Sea Urchin
Strong. purpuratus
XP_001177558
884
100012
S674
S
H
I
R
H
H
P
S
N
A
D
T
N
L
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
D579
R
L
T
D
E
A
S
D
H
I
A
T
S
Y
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P29469
868
98761
F677
T
E
P
I
L
S
R
F
D
I
L
C
V
V
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.8
87.4
N.A.
95.5
96
N.A.
93.1
88.2
86.7
80.1
N.A.
63.9
58.4
26.7
73.4
Protein Similarity:
100
99
96.1
89.1
N.A.
97.7
98.3
N.A.
95.7
93.8
93
87.6
N.A.
79.3
73.5
43.2
86.5
P-Site Identity:
100
100
0
33.3
N.A.
86.6
86.6
N.A.
80
53.3
46.6
60
N.A.
20
40
0
53.3
P-Site Similarity:
100
100
13.3
46.6
N.A.
100
100
N.A.
93.3
66.6
73.3
73.3
N.A.
40
66.6
20
66.6
Percent
Protein Identity:
N.A.
30.3
N.A.
N.A.
41.9
N.A.
Protein Similarity:
N.A.
48.8
N.A.
N.A.
58.9
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
0
0
0
13
7
7
7
0
13
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
0
7
0
0
0
% C
% Asp:
0
0
7
7
0
0
7
7
13
7
13
13
7
0
7
% D
% Glu:
0
7
0
0
7
0
0
0
0
7
38
32
38
7
13
% E
% Phe:
0
7
0
0
0
7
0
7
0
0
7
0
0
0
0
% F
% Gly:
13
0
0
0
0
0
0
7
0
7
7
7
7
32
13
% G
% His:
7
63
13
0
63
75
13
0
7
0
0
0
0
0
0
% H
% Ile:
0
0
25
19
0
0
0
0
0
13
0
7
7
13
0
% I
% Lys:
0
0
0
32
7
0
0
0
0
50
19
7
0
0
0
% K
% Leu:
0
7
0
0
13
0
0
0
0
0
7
7
0
7
32
% L
% Met:
0
0
7
7
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
50
7
0
0
7
13
0
% N
% Pro:
0
0
7
0
0
0
63
13
0
0
0
0
0
13
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% Q
% Arg:
13
0
0
32
7
0
7
0
7
0
0
0
0
0
7
% R
% Ser:
63
13
0
0
0
7
7
50
25
0
0
0
7
0
7
% S
% Thr:
7
0
7
7
0
0
0
13
0
0
7
13
7
0
0
% T
% Val:
0
7
38
0
0
0
7
7
0
0
0
7
13
13
13
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _